nanoXIM TCP is a calcium deficient hydroxyapatite powder consisting of nanostructured micron-sized aggregates.
This product is used to manufacture blocks, granules and calcium phosphate cements for bone replacement, allowing a gradual biological degradation over a period of time and a progressive replacement by the natural host tissue.
|Promotes fast bone regeneration and an early vascularization due to their osteoconductive and osteostimulative properties|
|Encourages protein adsorption and osteoblast adhesion|
|Enhances osteoblast functions|
|Resorbable material replaced by new bone during the healing process
|Pure calcium deficient hydroxyapatite|
|High surface area|
|Nanostructured micron sized powder|
nanoXIM•TCP200 powder is a synthetic calcium phosphate form commonly designated by calcium-deficient hydroxyapatite. Once sintered at 1000ºC (following ISO 13779 procedures), a minimum of 95% β-TCP phase purity is ensured in accordance with ASTM F1088-04ɛ1.
nanoXIM•TCP200 powder is supplied as synthetic nanostructured micron-size particles of 5 μm with a high specific surface area. This feature is achieved in the drying process by spray dryer technique where the nanoparticles in liquid phase are dried as spherical aggregates.
|Reference||Particle size, d50 (μm)|
nanoXIM TCP Powders
SEM of nanoXIM.TCP Powder
Electron crystallography image
K. Elhattab, S.B. Bhaduri, P. Sikder, “Influence of Fused Deposition Modelling Nozzle Temperature on the Rheology and Mechanical Properties of 3D Printed β-Tricalcium Phosphate (TCP)/Polylactic Acid (PLA) Composite”, Polymers, 14(6):1222. (2022)
C.A.G. Beatrice, K.M.B. Shimomura, E.H. Backes, S.V. Harb, L.C. Costa, F.R. Passador, L.A. Pessan, “Engineering printable composites of poly (ε‐polycaprolactone) / β‐tricalcium phosphate for biomedical applications”, Polymer Composites, DOI: 10.1002/pc.25893 (2020).
I.M. Pintão, “Development of a bi-functional 3D scaffold composed by glucomannan and biphasic calcium phosphates for bone tissue engineering applications.”, MSc Thesis in Bioengineering, Faculdade de Engenharia and Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto (2020).
E. H. Backes, L.N. Pires, H.S. Selistre-de-Araujo, L.C. Costa, F.R. Passador, L.A. Pessan, “Development and characterization of printable PLA/β-TCP bioactive composites for bone tissue applications”, Journal of Applied Polymer Science, 49759. doi:10.1002/app.49759 (2020).
J. Idaszek, T. Brynk, J. Jaroszewicz, F. Vanmeert, A. Bruinink, W. Święszkowski, “Investigation of mechanical properties of porous composite scaffolds with tailorable degradation kinetics after in vitro degradation using digital image correlation”, Polymer Composites, 38(11), p. 2402 (2017).
J. Idaszek, A. Bruinink, W. Święszkowski, “Delayed degradation of poly(lactide-co-glycolide) accelerates hydrolysis of poly(ε-caprolactone) in ternary composite scaffolds”, Polymer Degradation and Stability, 124, p. 119 (2016).
J. Idaszek, A. Bruinink, W. Święszkowski, “Ternary composite scaffolds with tailorable degradation rate and highly improved colonization by Human Bone Marrow Stromal Cells”, Journal of Biomedical Materials Research: Part A, 103(7), p. 2394 (2015).
L.R. Rodrigues, M.S. Laranjeira, M.H. Fernandes, F.J. Monteiro, C.A.C. Zavaglia, “HA/TCP scaffolds obtained by sucrose crystal leaching method: Preliminary in vitro Evaluation”, Materials Research, 17(4), p. 811 (2014).
K. Korzeb, J. Idaszek, W. Święszkowski, “Comparison of mechanical properties of Biodegradable PCL-based binary and ternary composites”, Engineering of Biomaterials, XV(116-117), p. 66 (2013).
L.R. Rodrigues, M.A. Ávila, F.J. Monteiro, C. A. Zavaglia, “Synthesis and characterization of nanocrystalline hydroxyapatite gel and its application as scaffold aggregation”, Materials Research, 15(6) p. 974 (2012)
L.R. Rodrigues, A.B. Almeida, D.F. Feliciano, C.E. Raposo-Amaral, M.R. Passos-Bueno, B.V. Alamada, M.H. Fernandes, F.J. Monteiro, C. A. Zavaglia, “Inclusão de células mesenquimais em scaffold de fosfato de cálcio para testes in vivo e in vitro”, presented at the “7 Congresso Latino-Americano de Orgãos Artificiais e Biomateriais”, Natal, Brazil (2012).