nanoXIM HAp pastes are nano-hydroxyapatite water based pastes specially recommended to manufacture bone graft substitutes such as injectables for bone regeneration and implants for hard tissues.
The hydroxyapatite nanoparticles comprised in these products form a perfectly aligned structure of nanocrystals.
Due to the similarity between nano-hydroxyapatite and mineralized bone, nanoXIM HAp pastes have a high affinity to hard tissues, establishing chemical bonds with the host tissue.
|Promotes fast bone regeneration and an early vascularization due to their osteoconductive and osteostimulative properties|
|Encourages protein adsorption and osteoblast adhesion|
|Enhances osteoblast functions|
|Resorbable material replaced by new bone during the healing process|
|Optimal defect filling capacity due to pasty consistency|
|Hydroxyapatite phase purity (100%)|
|Hydroxyapatite nanoparticles (< 50 nm)|
|High surface area (≥ 80 m2/g)|
nanoXIM•HAp100 is a series of synthetic nano-hydroxyapatite aqueous pastes, manufactured and supplied in two different concentrations, 15 and 30 wt%.
These products comprise nano-hydroxyapatite particles with typical particle size below 50 nm in a rod-like shape (typically 30-40 nm length and 5-10 nm width) suspended in pure water.
|Reference||Hydroxyapatite (wt%)||Specific surface area,
as Pb (ppm)
|nanoXIM•HAp102||15±1.0||≥ 80||≤ 20|
|nanoXIM•HAp103||30±3.0||≥ 80||≤ 20|
High Resolution TEM of
Electron crystallography image
During bone regeneration, Human Mesenchymal Stem Cells (HMSCs) play an important role as they are recruited to the injured place and differentiate into bone cells, enabling the regeneration process.
Considering the importance of these cells, it was evaluated the biological performance of nanoXIM•HAp102 in the proliferation and osteoblastic differentiation of HMSCs.
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