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nanoXIM HAp pastes are nano-hydroxyapatite water based pastes specially recommended to manufacture bone graft substitutes such as injectables for bone regeneration and implants for hard tissues.

The hydroxyapatite nanoparticles comprised in these products form a perfectly aligned structure of nanocrystals.

Due to the similarity between nano-hydroxyapatite and mineralized bone, nanoXIM HAp pastes have a high affinity to hard tissues, establishing chemical bonds with the host tissue.

 

 

   Benefits

 

Promotes fast bone regeneration and an early vascularization due to their osteoconductive and osteostimulative properties
Encourages protein adsorption and osteoblast adhesion
Enhances osteoblast functions
Biocompatible material
Resorbable material replaced by new bone during the healing process
Optimal defect filling capacity due to pasty consistency

 

   Features

 

Hydroxyapatite phase purity (100%)
Hydroxyapatite nanoparticles (< 50 nm)
 
High surface area
Synthetic material

 

 

 

 

   Technical Data Sheet

 

nanoXIM•HAp100 is a series of synthetic nano-hydroxyapatite aqueous pastes, manufactured and supplied in two different concentrations, 15 and 30 wt%.

These products comprise nano-hydroxyapatite particles with typical particle size below 50 nm in a rod-like shape (typically 30-40 nm length and 5-10 nm width) suspended in pure water.

 

Reference  Hydroxyapatite (wt%)  cart
nanoXIM•HAp102 15±1.0 ADD
nanoXIM•HAp103 30±3.0 ADD
Disclaimer: nanoXIM products are supplied in bulk and in non-sterile form.

 

nanoXIM.HAp Paste

High Resolution TEM of
nanoXIM.HAp Paste

Electron crystallography image
of nanoXIM.HAp Paste

 

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Stem Cells Applications of nano-HAp

 

During bone regeneration, Human Mesenchymal Stem Cells (HMSCs) play an important role as they are recruited to the injured place and differentiate into bone cells, enabling the regeneration process.

Considering the importance of these cells, it was evaluated the biological performance of nanoXIMHAp102 in the proliferation and osteoblastic differentiation of HMSCs.

 

Download Whitepaper

Human Mesenchymal Stem Cells (HMSCs) cultured in the
presence of nanoXIM HAp Paste present typical cytoskeleton
organization.

 

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Y. Liu, S. Sebastian, J. Huang, T. Corbascio, J. Engellau, L. Lidgren, M. Tägil, D.B. Raina, “Longitudinal in vivo biodistribution of nano and micro sized hydroxyapatite particles implanted in a bone defect”, Front. Bioeng. Biotechnol. 10:1076320 (2022).

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A. Mahfuri, A. Shehada, K. Darwich, R. Saima, “Radiological Comparative Study Between Conventional and Nano Hydroxyapatite With Platelet-Rich Fibrin (PRF) Membranes for Their Effects on Alveolar Bone Density”, Cureus 14(12): e32381 (2022).

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H Yue, Q Zhu, S Dong, Y Zhou, Y Yang, L Cheng, M. Qian, L. Liang, W. Wei, H. Wang “A Nanopile Interlocking Separator Coating towards Uniform Li Deposition of the Li Metal Anodes” ACS Appl. Mater. Interfaces, doi:10.1021/acsami.0c08776 (2020).

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R.V. Pinto, P.S. Gomes, M.H. Fernandes, M.E.V. Costa, M.M. Almeida, “Glutaraldehyde-crosslinking chitosan scaffolds reinforced with calcium phosphate spray-dried granules for bone tissue applications”, Materials Science & Engineering C, 109, 110557, doi:10.1016/j.msec.2019.110557 (2020) .

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I. Corvaglia, “Design and optimization of hybrid formulations based on PLLA and inorganic phases for 3D printing of bone scaffolds”, MSc thesis in Biomedical Engineering, Politecnico di Torino (2020).

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Influence of PLLA/PCL/HA Scaffold Fiber Orientation on Mechanical Properties and Osteoblast Behavior

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C. Santos, S. Turiel, P.S. Gomes, E. Costa, A. Santos Silva, P. Quadros, J. Duarte, S. Battistuzzo, M.H. Fernandes, “Vascular biosafety of commercial hydroxyapatite particles: discrepancy between blood compatibility assays and endothelial cell behavior”, Journal of Nanobiotechnology, 16(27), doi: 10.1186/s12951-018-0357-y (2018).

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Chitosan based scaffolds for bone regeneration

L. Marbelia, “Chitosan based scaffolds for bone regeneration” MSc Thesis, University of Aveiro (2011).

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Matrizes de quitosano/grânulos bifásicos para libertação de fármacos

Mesquita, “Matrizes de quitosano/grânulos bifásicos para libertação de fármacos (Chitosan/biphasic granules scaffolds for drug delivery)” MSc Thesis, Aveiro University (2012).

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