30 July 2019.
Is it SAFE to use NANO hydroxyapatite in toothpastes?
The latest research study say YES, at least in which specifically concerns nanoXIM Hydroxyapatite manufactured by FLUIDINOVA.
This recent study entitled “Nano-hydroxyapatite in oral care cosmetics: characterization and cytotoxicity assessment” conducted at Bone Lab from U.Porto shows that nanoXIM hydroxyapatite can be considered as a safe nanomaterial to be used in toothpastes. The researchers responsible for this study evaluated the cytotoxicity parameters of the nanoXIM hydroxyapatite in several in vitro trials following the European Commission SCCS guidelines and concluded that this nanomaterial is highly cytocompatible towards human gingival fibroblasts and therefore can be considered as safe to be used in oral care products.
Together with the previous paper “Safety Assessment of Nano-Hydroxyapatite as an Oral Care Ingredient according to the EU Cosmetics Regulation” by Ramis et al. (2018), this study produced new knowledge regarding this nanomaterial when used in toothpastes and similar oral care products, presenting a complete set of information to prove its safety and answering the open questions of the SCCS/1566/15 Opinion.
11-12 July 2019, Heraklion, Crete, Greece.
FLUIDINOVA was present at GIOTTO project - Active aGeIng and Osteoporosis: The next challenge for smarT nanobiOmaterials and 3D technologies - M6 Technical Meeting held in Heraklion (Crete – Greece).
Check out the project website to find out more about the event and this project.
27th – 31st May 2019, Rhodes, Greece.
For the full week, FLUIDINOVA will be present at Tissue Engineering and Regenerative Medicine International Society (TERMIS) European Chapter Meeting in Rhodes. The theme of this year meeting will be ‘Tissue Engineering Therapies: From concept to clinical translation and commercialisation’.
Researchers, industries and clinicians will get together to revolutionise tissue engineering in healthcare. See you in Rhodes!
12-14 March 2019, Cologne, Germany.
4-5 February 2019, Brussels, Belgium.
GIOTTO project kick-off meeting was held in Brussels on February 4th and 5th 2019. Representatives of the 14 partner institutions from 10 European Countries gathered together with the European Commission officer, Dr. Matteo Bonazzi, the advisory board and the Project Coordinator Prof. Chiara Vitale-Brovarone from Politecnico di Torino (Italy), to detail the plan of activities for the first year of the project.
15 October 2018, Porto, Portugal.
FLUIDINOVA was recognized as a FEUP Prime Affiliate and received its certificate at the event held at University of Porto. FEUP Prime is a corporate membership programme that provide real value and competitive advantages to the companies, establishing a direct connection to the sources of talent and knowledge that will give the ability to stay ahead and deliver key innovations to the market.
Affiliates are companies recognized by their long lasting or strong relations with the University of Porto engineering departments, established through cooperation in dissertations, internships and other project studies, or in sponsored research and tech transfer activities.
10 - 11 October 2018, IFEMA Madrid, Spain.
FLUIDINOVA will be present at the world’s largest pharmaceutical exhibition, CPhI Worldwide. This show houses six individual pharma events covering all industry sectors, from ingredients and FDF, to machinery, packaging, outsourcing and biopharmaceuticals.
11 September 2018.
The safety of nanoXIM hydroxyapatite materials is one of our primary concerns, since they are used in consumer health products and medical devices. Particularly, the safety assessment of nano-hydroxyapatite used in toothpastes and related oral care products is of main interest to the public, as this ingredient is becoming more and more popular among toothpaste and mouthwash formulators and brands due to its renowned efficacy.
Following the Opinion issued by the European Commission Scientific Committee on Consumer Safety in March 2016 (SCCS/1566/15), where an extended review as made about the safety of nano-hydroxyapatite (including nanoXIM.CarePaste), a new research published in the Cosmetics journal from MDPI was now done to complement the results scrutinized in this Opinion.
In this joint research lead by Universitat de les Illes Balears, the safety and biocompatibility of nanoXIM.CarePaste was assessed and proved by showing no cytotoxic or deleterious effect on gingival tissue for much harsher conditions (longer contact times and higher concentrations) that the real ones found when using these daily hygiene products.
Besides its already well-known proven efficacy, this research concludes and reinforces that nanoXIM.CarePaste hydroxyapatite is also a safe oral care ingredient!
9-13 September 2018, Maastricht, Netherlands.
From 9th to 13th September, FLUIDINOVA will be present at the 29th European Conference on Biomaterials in Maastricht. The Annual Conference of the European Society for Biomaterials (ESB) has been the main event for the biomaterial science and regenerative medicine community. During 5 days, scientists, clinicians and industrialists with different backgrounds and expertise gather to advance the field of biomaterials by presenting their latest research. FLUIDINOVA is proud to attend ESB 2018 to present the latest research performed with nanoXIM hydroxyapatite in the poster entitled “Preventing dental and orthopaedic infections with a bone substitute of nanohydroxyapatite and magnesium oxide”.
Feel free to visit our poster on the 11th September in poster section B, from 1:00 to 2:00 PM.
15 and 16th March 2018, Madrid, Spain.
FLUIDINOVA will be present once again at the ExpoDental, to follow the latest news in the oral hygiene and dental bone grafts in Spain. A great opportunity to check the latest innovations and trends within this particularly active oral care market.
FLUIDINOVA wishes to all its customers, suppliers, stakeholders and friends Peace, Joy and Happiness!
25 - 27 October 2017, Toulouse, France.
As a sponsor for the 29th Symposium and Annual Meeting of the International Society for Ceramics in Medicine (Bioceramics 29), FLUIDINOVA is proud to be present in Toulouse to promote the recent research conducted with nano-hydroxyapatite nanoXIM materials. In cooperation with prestigious research groups in Portugal, FLUIDINOVA will showcase the following two posters:
Come visit our posters to learn more about the latest developments on nano-hydroxyapatite.
See you in Toulouse!
24 - 26 October 2017, Messe Frankfurt, Germany.
FLUIDINOVA will be present at the CPhI Worldwide 2017. CPhI Worldwide, together with co-located events ICSE, InnoPack, P-MEC and FDF, hosts more than 42,000 visiting pharma professionals over three days and 2500+ exhibitors from 153 countries. This event will be a great opportunity for FLUIDINOVA to create new partnerships and promote nanoXIM products.
16 October 2017
FLUIDINOVA is proud to announce our ISO 9001 standard certification renewal from ISO 9001:2008 to the newly revised standard, ISO 9001:2015.
As a previously ISO 9001:2008 certified organization, we have successfully completed the transition to the 2015 revision nearly one full year before the deadline to do so.
As part of the ISO 9001:2015 certification process, FLUIDINOVA engaged in a rigorous audit of our business processes as well as our product quality environments.
By achieving this level of certification we continue to demonstrate our ability and desire to effectively and efficiently provide a quality management system, while continuously improving our products as well as our internal processes.
21-24 March 2017, Cologne, Germany.
FLUIDINOVA will be present at the 37th International Dental Show – IDS 2017. This is the major international exhibition on the dental sector, where around 2.300 exhibitors from 60 countries will present the latest products, developments and trends of the dental industry. More than 140.000 international trade visitors are expected to attend.
For the 3rd consecutive time, FLUIDINOVA will be present to meet their customers that will be exhibiting their innovative oral care and biomaterials’ products integrating nanoXIM hydroxyapatite.
14-18 March 2017, San Diego, California, USA.
From 14th to 18th March, FLUIDINOVA will be present at the Annual Meeting of the American Academy of Orthopaedic Surgeons (AAOS), the world’s largest medical association of musculoskeletal specialists. The Annual Meeting is the AAOS premier event with more than 30.000 participants, including AAOS members, international guests, health professionals and exhibitors. Representatives from over than 600 companies will attend this meeting, being the largest gathering of companies displaying products and services specifically for orthopaedics. This event will be a great opportunity for FLUIDINOVA to create new partnerships and promote nanoXIM products for bone regeneration.
Please let us know if you want to meet us at the 2017 AAOS Annual Meeting. See you in San Diego!
28-30 November 2016, New York, USA.
FLUIDINOVA will be visiting this year the 92nd Annual Greater New York Dental Meeting (GNYDM), from Nov 28 to 30th in NY, USA. It will be a good opportunity to see the latest innovations and trends in Dental Care, including dentifrices and bone graft materials, where nanoXIM hydroxyapatite products can play a major role. If you want to meet us in NY, please contact us to schedule a meeting.
26-29 October 2016, Boston, USA.
FLUIDINOVA is going to attend the North American Spine Society (NASS) Annual Meeting in Boston, on 26-29th October. In this meeting, professionals from around the globe will share the newest techniques and technologies for spine care. This will be a great opportunity for FLUIDINOVA to present nanoXIM products for bone repair and regeneration. Our team is looking forward to establish new business partnerships with the most innovative companies in the spine industry.
6-7 October 2016, Berlin, Germany.
On 6th and 7th October, FLUIDINOVA will be present at EUROSPINE 2016 in Berlin. This conference will be attended by the greatest spine specialists and leader companies in the spine industry. FLUIDINOVA’s team will have the opportunity to meet partners and customers to reinforce its position in the spine field and promote the nanoXIM products for medical applications.
10-11 May 2016, New Jersey, USA.
FLUIDINOVA is attending the 2016 Suppliers’ Day organized by the New York Society of Cosmetic Chemists. This two-day event held at the New Jersey Convention and Exposition Center showcases new products and the latest innovations. As always, FLUIDINOVA is at the front edge of science, technology and marketing, looking for new business opportunities and to promote the nanoXIM products.
October 2015, Portugal.
A decade ago, FLUIDINOVA was starting as a spin-off of University of Porto and taking the first baby steps on the complex world of business. Determined to develop and exploit new technologies, FLUIDINOVA earlier started developing its NETmix technology to produce nano-hydroxyapatite, which would be later commercialized under the brand nanoXIM. Recognized from the beginning by important research centres and Universities as a high quality material, FLUIDINOVA’s nano-hydroxyapatite soon started to be used by several medical devices manufacturers to fabricate synthetic bone substitutes. A couple of years later, FLUIDINOVA designed a special product to enter the Oral Care business where nano-hydroxyapatite could replace conventional desensitizing and remineralizing technologies, enhancing the new products performance.
Today, FLUIDINOVA and nanoXIM products are globally recognized as a synonym of quality, high performance and innovation. Through our customers, our products are now present all over the world in biomaterials medical devices and oral care products and in the most reputable university and R&D centres.
Today it’s time to celebrate!
Happy birthday FLUIDINOVA!
14-16 April 2015, Barcelona, Spain.
FLUIDINOVA will be once more in “The leading global business event for personal care ingredients” - In Cosmetics 2015.
After being in Paris and Milan in the previous editions, this time FLUIDINOVA team will be attending In Cosmetics 2015 in Barcelona where will have the opportunity to meet with partners and customers in order to continue to develop the nanoXIM hydroxyapatite business for the Personal Care Industry.
Contact us to schedule a meeting on the 14 or 15th April.
10-14 March 2015, Cologne, Germany.
FLUIDINOVA will be visiting the International Dental Show IDS2015 in Cologne, Germany to meet their customers and see in loco the new Oral Care products that are arriving the market incorporating nanoXIM hydroxyapatite. Once again, this year several new Oral Care products using nanoXIM technology will be launched into the market at IDS.
10-13th September 2014, Dubrovnik, Croatia.
FLUIDINOVA will be attending this IADR/PER Congress in Dubrovnik, Croatia to present to the scientific community an update from the IMCOSS project for “Injectable Medical Ceramics for Bone Repair and Augmentation” sponsored by EU FP7. Together with the other project partners, FLUIDINOVA will show and discuss with the congress delegates the latest results achieved in this research project. For more information, visit our booth at the IADR/PER 2014.
7th July 2014, Porto, Portugal.
Christos Tokamanis, Head of Unit "Nano and converging Sciences and Technologies" at DG Research, European Commission, was visiting CCDR-N and CeNTI, where he had the opportunity to contact with the cutting-edge nanomaterials products and technologies currently available in Portugal.
FLUIDINOVA was invited to participate in this event in order to show its nanoXIM hydroxyapatite materials as an example of a leading EU advanced nanomaterial technology already used in the market of bone regeneration and consumer oral care products.
During the event, FLUIDINOVA representatives had the opportunity to introduce and to discuss with Mr. Tokamanis the benefits of nanoXIM nanomaterials and its presence in the EU market.
7-8th May 2014, Nantes, France.
In the scope of NEWGEN COST project, FLUIDINOVA as an active member of WG1 will attend the Workshop on Biomaterials being held at the Dental School of Nantes from 7-8th May 2014. Dr. Paulo Quadros from FLUIDINOVA will participate in a joint talk under the topic “Nanocrystalline apatite: from fundamentals to bone substitute materials”. The workshop follows the GRIBOI 2014 - Injectable Osteoarticular Biomaterials and Bone Augmentation Procedures Conference organized by University of Nantes from 5-7th May.
This COST Action, NEWGEN, aims at creating the seed for the European research and industry collaboration, combining basic knowledge from academic laboratories, R&D centres, medical units from hospitals, and a significant number of companies.
13-14th March 2014, Madrid, Spain.
Strengthening each day its position as a reference in the Oral Care market as a high quality manufacturer and supplier of nanohydroxyapatite, FLUIDINOVA will visit EXPODENTAL - International Dental Equipment, Supplies and Services Show in Madrid, Spain from 13-14th March. This will be a good opportunity to visit our exhibiting customers, meet new partners and seek new business opportunities both in Oral Care as well in Medical Devices, with the focus on Biomaterials and Bone Substitutes. If you plan to attend this International Exhibition in Madrid, please contact us in advance to schedule a meeting and meet our team. FLUIDINOVA team looks forward seeing you at EXPODENTAL 2014!
14th March 2014, Torino, Italy.
FLUIDINOVA will attend the Working Groups meeting held in Torino, Italy, involving all partners to discuss project strategies and initiatives.
With a predicted ageing population and increasing expectations regarding quality of life in old age, there is an ever increasing demand for procedures such as total hip replacements, bone reconstructions, and spinal fusions, resulting from conditions such as articular cartilage degeneration and osteoporosis.
Commercial calcium phosphate composites for bone regeneration are restricted to applications that require only moderate load bearing abilities. High toughness bioinert materials are used in the articulating couple of artificial joint implants, but they do not support direct bone/material interfaces or bond. To date there is no tough and strong ceramic in regular clinical use with ability to create a strong, biologically relevant, interface with bone.
New advances in biomaterials, with improved processing, bioactivity and/or tailored shapes, providing enough structural integrity and bone integration/regeneration are currently in development at the laboratory scale. However, due to the gap between academic R&D and commercial production, and between materials scientists and clinicians, medical application of these new materials will never be possible unless companies and medics are involved in the development.
This COST Action, NEWGEN, aims at creating the seed for the European research and industry collaboration, combining basic knowledge from academic laboratories, R&D centres, medical units from hospitals, and a significant number of companies.
20- 21st January 2014, Gland, Switzerland.
The first year progress meeting of the project “Injectable Medical Ceramics for Bone Repair and Augmentation – IMCOSS” was held in Gland, Switzerland in January 2014. FLUIDINOVA and its partners were present to discuss the project progress and the future developments for the second year of this FP7 sponsored project involving the nanohydroxyapatite from FLUIDINOVA.
28th November 2013, Vienna, Austria.
The second IMCOSS clinical workshop involving the nanoXIM hydroxyapatite paste material took place in Vienna on the 28th November 2013. FLUIDINOVA and all SME and Research partners’ were present for the trial of the optimised material and delivery device. Orthopaedic and dental surgeons provided valuable feedback and advised the IMCOSS team on potential advancements to the basic and optimized materials.
The overall feedback was promising and the IMCOSS consortium will now investigate advanced materials to address the surgical needs and potentially improve biological function.
13th September 2013, Madrid, Spain.
FLUIDINOVA is a member of the new COST MP1301 “New Generation Biometric and Customized Implants for Bone Engineering” project and will attend on September 13th the first partners meeting at Instituto de Cerámica Y Vidrio in Madrid, Spain.
The project involves 70 partners from 19 countries and will last until 2018. The goal of this “know each other” meeting is to get the partners with common interests to the project familiarized with each other activities and prepare the kick-off meeting that will take place in Brussels, Belgium on October 2nd.
12-16 March 2013, Cologne, Germany.
This year FLUIDINOVA will be visiting the International Dental Show IDS 2013 in Cologne, Germany, the world's leading trade fair for the dental sector. This visit will be a great opportunity to meet or see us again and to discuss any issue related with our nanoXIM hydroxyapatite product.
Please contact us in advance to schedule a meeting.
FLUIDINOVA team looks forward seeing you at IDS 2013!
A quantitative in vitro dentin tubule blockage evaluation study of a dentifrice containing nanoXIM•CarePaste was carried out. The study demonstrates that nanoXIM•CarePaste material can act as a hypersensitivity teeth reducer active ingredient, since the toothpaste developed with nanoXIM•CarePaste was able to occlude more than 75% of the dentine tubules. Moreover, an improvement of the smoothness of the tooth surface, due to the deposition of nanohydroxyapatite on enamel surface, would enable to have brighter and whiter teeth. In conclusion, the incorporation of nanoXIM•CarePaste in toothpastes and similar oral care products will lead to very promising results in dentin tubule blockage, foreseeing a great potential for nanoXIM•CarePaste as an enamel remineralizing agent and hypersensitivity reducer.
29-30 March 2011, Milan, Italy.
FLUIDINOVA will be visiting In-Cosmetics 2011 Exhibition once again in order to meet our customers and potential new users for nanoXIM.Care hydroxyapatite product. In-Cosmetics brings together the world’s leading personal care ingredients suppliers, formulators, R&D and marketing specialists and showcases the most diverse range of innovative cosmetics ingredients and technologies. If you wish to meet us in Milan during 29 or 30th March, please contact us in order to schedule a meeting. We look forward to meeting you at In-Cosmetics 2011.
As a result of a cooperation between FLUIDINOVA S.A. and INEB – Instituto de Engenharia Biomédica, Portugal, within the research project “Development and scale-up of 3D structures and coatings for medical applications based on nanosized hydroxyapatite- NanoforBone”financed by the Portuguese Agency for Innovation (ADI) under QREN program, two scientific papers involving the study of the nanohydroxyapatite nanoXIM produced by FLUIDINOVA have been recently published. The papers stated the advantages of using nanostructured nanoXIM hydroxyapatite in bone scaffolds substitutes and also the influence of the hydroxyapatite crystal size on proteins adsorption and osteoblast adhesion. Further information can be found in Laranjeira et al (2010) and Ribeiro et al (2010).
December 2010, Coimbra, Portugal.
FLUIDINOVA was present in the PILLS Dissemination Event held over two days at University of Coimbra, Portugal. FLUIDINOVA is contributing to PILLS project with its innovative reactor technology NETmix® which will be integrated in the Experimental Research Facility during the first quarter of 2011 to conduct experimental trials. Dr. Paulo Quadros and Erdem Demir presented FLUIDINOVA, PILLS projects and other projects that demonstrate the industrial applicability of NETmix® which was well-received by the audience. The event included interactive presentations on the technical status and progress of the project, updates on the development of a multi-purpose plant for evaluation of micro-reactors in specialty chemical production and also included a guided tour of the new Experimental Research Facility showcasing both the micro and meso-structured reactors and discussions on future exploitation of the technology. The PILLS (Process Intensification methodologies applied to Liquid-Liquid Systems in structured equipment) project is a €5.5 million collaborative R&D project funded under the European Commission’s Seventh Framework Programme. The project is made up of a consortium of 10 partners from across Europe – Givaudan, Warsaw University,FLUIDINOVA, Huntsman, IMM, University of Coimbra, Chemistry Innovation, Britest, EPFL and CUF-QI.
in https://www.emdt.co.uk/, September 2010
Manufactured as a raw material for bone substitution and other medical technology applications, a line of high-purity, single-phase, nanocrystalline hydroxyapatite nanoparticles comply with ISO 13779 and ASTM F1185 standards respecting heavy metals and phase purity. The synthetic nanocrystals in the nanoXIM·HAp products feature a perfectly aligned structure, and the materials exhibit a high level of consistency. These nanoparticles have a high specific surface BET area of greater than 100 m2/g, and the precise stoichiometry of calcium and phosphate ions results in a calcium-to-phosphate ratio always near 1.67. The materials are produced in paste form at a nano-hydroxyapatite concentration of 15 or 30% by weight in pure water, a convenient resorbable material for applications such as bone injectable substitutes, and as spray-dried powders of pure hydroxyapatite in particle sizes of 2.5, 5 and 10 µm, suitable for bone grafts and drug-delivery systems.
On October 17, FLUIDINOVA reached one of its main goals for 2008 obtaining the Certification by SGS of its Quality Management System according to the standard NP EN ISO-9001:2000 in the scope of Design and Development of New Industrial and Environmental Technologies and Products, as well as in the Production of Hydroxyapatite Nanoparticles. At FLUIDINOVA, we are sure that the Certification of our Quality Management System represented a major step for the future projection of our company and we are committed to the maintenance of quality in the goods and services that we provide, aiming at the full satisfaction of our clients.
27-28th October 2008, London, UK.
FLUIDINOVA, invited by the UK Trade & Investment Team at the British Embassy Lisbon, will participate in the UK NanoForum 2008 that will take place in London during 27 and 28th October 2008. This third annual UK NanoForum comprises a one-day conference and exhibition bringing over 100 senior international delegates from more than 20 countries, together with the best of the UK's nanotechnology community.